TOXICITY OF MIXTURES OF ORGANIC CHEMICALS TO MICROORGANISMS by N. Nirmalakhandan, et. al.
Wat. Res. Vol. 28, No. 3, pp. 543-551, 1994
Approaches developed by toxicologists in
analyzing joint effects of two or more chemicals on fish were used to analyze
and predict joint effects on microorganisms. Based on the results, the joint
toxic effects of the 50 chemicals tested in this study can be considered simply
additive. A quantitative structure-activity relationship (QSAR) technique is
proposed for predicting the concentrations of the components of a mixture that
would cause 50 % inhibition by joint action. The concentrations predicted by
the proposed QSAR method are shown to agree well with those experimentally
measured with r2 = 0.8 at a level of significance, P = 0.0001.
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